1. Sommer F，Bäckhed F. The gut microbiota—masters of host development and physiology. Nat Rev Microbiol，2013，11：227-238.

2. 武庆斌，郑跃杰，黄永坤.儿童肠道菌群-基础与临床.北京：科学出版社，2012：67-93.

3. Wall R，Ross R P，Ryan C A，et al. Role of gut microbiota in early infant development. Clin Med Pedia，2009，3：45.

4. Huurre A，Kalliomäki M，Rautava S，et al. Mode of deliveryeffects on gut microbiota and humoral immunity. Neonatal，2007，93：236-240.

5. McGhee J R，Fujihashi K. Inside the mucosal immune system. PLoS Biol，2012，10：e1001397.

6. Ogra P L. Ageing and its possible impact on mucosal immune responses. Ageing Res Rev，2010，9：101-106.

7. Macpherson AJ，Harris N L. Interactions between commensal intestinal bacteria and the immune system. Nat Rev Immunol，2004，4：478-485.

8. Macpherson AJ，Harris NL. Interactions between commensal intestinal bacteria and the immune system. Nat Rev Immunol，2004，4：478-485.

9. Clarke TB，Davis KM，Lysenko ES，et al. Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity. Nat Med，2010，16：228-231.

10. Hooper LV，Littman DR，Macpherson AJ. Interactions between the Microbiota and the Immune System.Science，2012，336：1268.

11. Cani PD，Delienne NM. Gut microflora as a target for energy and metabolic homeostasis. Curr Opin Clin Nutr Metab Care，2007，10：729-734.

12. Backhed F，Ley RE，Sonnenburg GL，et al. Host-bacterial mutualism in the human intestine. Science，2005，307：1915-1920.

13. Xu J，Gordon JI. Honor thy symbionts. Proc Natl Acad Sci USA，2003，100：10452-10459.

14. Eckburg PB，Bik EM，Bernstein CN，et al. Diversity of the human intestinal microbial flora. Science，2005，308：1635-1638.

15. Turnbaugh PJ，Bäckhed F，Fulton L，et al. Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe，2008，3：213-223.

16. Rawls JF，Mahowald MA，Ley RE，et al. Reciprocal gut microbioa transplants from zebrafish and mice to germ free recipients reveal host habitant selection. Cell，2006，127：423-433.

17. Kalliomäki M，Collado MC，Salminen S，et al. Early differences in fecal microbiota composition in children may predict over weight. Am J Clin Nutr，2008，87：534-538.

18. Mai V，Draganov PV. Recent advances and remaining gaps in our knowledge of associations between gut microbiota and human human health. World J Gastroenterol，2009，15： 81-85.

19. Turnbaugh PJ，Hamady M，Yatsunenko T，et al. A core gut microbiome in obese and lean twins. Nature，2009，457：480-484.

20. He ZQ，Zhen Y，Liang C，et al. Vicious cycle composed of gut flora and visceral fat a novel explanation of the initiation and progression of a theroscleerosis. Med Hypotheses，2008，70：808-811.

21. Danielsen M，Hornshøj H，Siggers RH，et al. Effects of bacterial colonization on the porcine intestinal proteome. Proteome Res，2007，6：2596-2604.

22. Turnbaugh PJ，Ley RE，Mahowald MA，et al. An obesityassociated gut microbiome with increased capacity for energy harvest. Nature，2006，444：1027-1031.

23. Bäckhed F，Ding H，Wang T，et al. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci USA，2004，101：15718-15723.

24. Martin FP1，Dumas ME，Wang Y，et al. A top-down systems biology view of microbiome mammalian metabolic interactions in a mouse model. Mol Syst Biol，2007，3：112.

25. Duncan SH，Lobley GE，Holtrop G，et al. Human colonic microbiota associated with diet obesity and weight loss. Int J Obes Iond，2008，32：1720-1724.

26. Ley RE，Backhed F，Turnbaugh P，et al. Obesity alters gut microbial ecology. Proc Natl Acad Sci USA，2005，102：11070-11075.

27. Ley RE，Turnbaugh PJ，Klein S，et al. Microbial ecology：human gut microbes associated with obesity. Nature，2006，444：1022-1023.

28. Hill JO. Understanding and addressing the epidemic of obesity：an energy balance perspective. Endocr Rev，2006，27：750-761.

29. Kok N，Roberfroid M，Robert A，et al. Involvement of lipogenesis in the lower VLDL secretion induced by oligofructose in rats. Br J Nutr，1996，76：881-890.

30. Fiordaliso M，Kok N，Desager JP，et al. Dietary oligofructose lowers triglycerides phospholipids and cholesterol in serum and very low density lipoproteins of rats. Lipids，1995，30：163-167.

31. Psomas EI，Fletouris DJ，Litopoulou-Tzanetaki E，et al. Assimilation of cholesterol by yeast strains isolated from infant feces and Feta cheese. J Dairy Sci，2003，86：3416-3422.

32. Ramagsamy K，Abdullah N，Wong MC，et al. Bile salt deconjugation and cholesterol removal from media by Lactobacillus strains used as probiotics in chickens. J Sci Food Agric，2010，90：65-69.

33. Liong MT，Shah NP. Acid and bile tolerance and cholesterol removal ability of lactobacilli strains. J Dairy Sci，2005，88：55-66.

34. Pereira DI，McCartney AL，Gibson GR. An in vitro study of the probiotic potential of a bile-salt-hydrolyzing lactobacillus fermentum strain and determination of its cholesterollowering properties. Appl Environ Microbiol，2003，69：4743-4752.

35. Guarner F，Malagelada JR. Gut flora in health and disease. Lancet，2003，361：512-519.

36. 杨桂彬，胡伏莲. 胃肠屏障的生理基础. 中国临床营养杂志，2008，16：302-305.

37. 郑盛，刘海. 肠黏膜屏障功能障碍研究进展. 实用肝脏病杂志，2008，11：139-142.

38. Gagnon M，Kheadr E E，Le Blay G，et al. In vitro inhibition of Escherichiacoli O157：H7 by bifidobacterial strains of human origin. Int J Food Microbiol，2004，92：69-78.

39. Menard S，Candalh C，Bambou J C，et al. Lactic acid bacteria secrete metabolites retaining anti-inflammatory properties after intestinal transport. Gut，2004，53：821-828.

40. Lutgendorff F，Nijmeijer RM，Sandström PA，et al. Probiotics Prevent Intestinal Barrier Dysfunction in Acute Pancreatitis in Rats via Induction of lleal Mucosal Glutathione Biosynthesis. PLoS ONE，2009，4：e4512.

41. Penna FJ，Péret LA，Vieira LQ，et al. Probiotics and mucosal barrier in children. Curr Opin Clin Nutr Metab Care，2008，11：640-644.

42. Zyrek AA，Cichon C，Helms S，et al. Molecular mechanisms underlying the probiotic effects of Escherichia coil Nissle 19l7 involve ZO-2 and PKCzeta redistribution resulting in tight junction and epithelial barrier repair.Cell Microbio1，2007，9：804-816.

43. Cerutti A，Rescigno M. The biology of intestinal immunoglobulin A responses.Immunity，2008，28：740-750.

44. Rakoff-Nahoum S，Paglino J，Eslami-Varzaneh F，et al. Recognition of commensal microflora by toll-Like receptors is required for intestinal homeostasis. Cell，2004，118：229-241.

45. Lundin A，Bok CM，Aronsson L，et al. Gut flora，Toll-like receptors and nuclear receptors：a tripartite communication that tunes innate immunity in large intestine. Cell Microbiol，2008，10：1093-1103.

46. Petnicki-Ocwiejaa T，Hrncirc T，Liua YJ，et al. Nod2 is required for the regulation of commensal microbiota in the intestine.PNAS，2009，106：15813-15818.

47. Vinderlora.G，Matar.C. Milk fermented by Lactobacillus helveticusR389 and its non-bacterial fraction confer enhanced protection against Salmonella enteritidis serovar Typhimurium infection in mice. Immunobiology，2007，212：107- l18.